Table 3.
Associations Between Cognitive Function and Imaging Parameters
| Gray Matter Volume Regression Estimate (T-score/mL) |
HIV–Gray Matter Interaction | ||||
|---|---|---|---|---|---|
| Cognitive Domain | Estimate | (95% CI) | P Value | t203 | P Value |
| Attention | 0.035 | (–.001 to .072) | .06 | 1.91 | .06 |
| Executive function | 0.041 | (.013–.068) | <.01 | 0.75 | .45 |
| Memory | 0.010 | (–.016 to .037) | .43 | –0.67 | .50 |
| Motor function | 0.029 | (.001–.057) | .04 | 0.69 | .49 |
| Processing speed | 0.017 | (–.010 to .043) | .21 | 0.76 | .45 |
| Global | 0.026 | (.006–.046) | .01 | 1.34 | .18 |
| Fractional Anisotropy Regression Estimate (T-score/Unit FA) |
HIV-Fractional Anisotropy Interaction | ||||
| Estimate | (95% CI) | P Value | t199 | P Value | |
| Attention | 0.099 | (.013–.187) | .03 | –1.67 | .09 |
| Executive function | 0.073 | (.008–.139) | .03 | –0.62 | .54 |
| Memory | 0.035 | (–.028 to .097) | .27 | –0.53 | .60 |
| Motor function | 0.079 | (.013–.144) | .02 | 1.25 | .21 |
| Processing speed | 0.092 | (.031–.152) | <.01 | –0.41 | .68 |
| Global | 0.062 | (.014–.110) | .01 | –0.63 | .53 |
Multiple linear regression estimates for gray matter volume and FA by cognitive domain adjusted for age, intracranial volume, and scanner type. In addition, HIV status and neuroimaging measure interaction statistics for each cognitive domain are shown.
Abbreviations: CI, confidence interval; FA, fractional anisotropy; HIV, human immunodeficiency virus.