Figure 3.
Estradiol levels are higher in lopinavir/ritonavir (LPV/r)–treated women and lower in efavirenz (EFV)–treated women compared with levels in gestational week–matched combination antiretroviral therapy (cART)–naive women (prerandomization). Loge-transformed estradiol levels in plasma collected between gestational week (GW) 16 and <20 (A), 20 and <24 (B), and 24 and <28 (C). Data shown in circles (red for those who went on to be randomized to EFV and gray for those who went on to be randomized to LPV/r) are from prerandomization samples collected prior to cART initiation (enrol), data in red squares are from samples exposed to EFV, and data in gray triangles are from samples exposed to LPV/r. Statistical significance assessed by Kruskal-Wallis test with Dunn posttest.