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. 2018 Mar 5;131(5):532–538. doi: 10.4103/0366-6999.226065

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Copyright: © 2018 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of exogenous FGF21 on the blood creatinine level in VDN-induced VC rats (n = 8; a); effect of exogenous FGF21 on the urea level in VDN-induced VC rats (n = 8; b); effect of exogenous FGF21 on the histopathology of kidney in VDN-induced VC rats (original magnification ×200). The histological sections of kidney were stained by H and E. The pathologic changes of glomerulus atrophy were marked by white arrows and prominent renal interstitial fibrosis were marked by yellow arrows (c). *P < 0.01 compared with the normal control group. ^†P < 0.01 compared with the VDN group. FGF21: Fibroblast growth factor 21; VC: Vascular calcification; VDN: Vitamin D3 plus nicotine.