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Effect of exogenous FGF21 on the levels of renal β-Klotho in the kidney of VDN-induced VC rats (n = 8) by ELISA (a). Effect of exogenous FGF21 on the levels of renal FGFR1 in VDN-induced VC rats (n = 8) by ELISA (b). *P < 0.01 compared with the normal control group. †P < 0.05 compared with the VDN group. FGF21: Fibroblast growth factor 21; VC: Vascular calcification; VDN: Vitamin D3 plus nicotine; ELISA: Enzyme-linked immunosorbent assay.
