Table II.
Adjusted risk ratio (95% CI) of clinical outcomes per initiated treatment cycle for every 1% increase in serum fatty acid concentrations in 100 women who underwent 136 ART cycles within 1 year of blood sample collection, the Environment and Reproductive Health (EARTH) Study.
| Serum fatty acids | Implantation | Clinical pregnancy | Live birth |
|---|---|---|---|
| RR1 (95% CI) per 1% increase in serum concentration | |||
| 18:3 ω-3 ALA | 0.57 (0.29, 1.10) | 0.47 (0.24, 0.92) | 0.49 (0.18, 1.31)† |
| 20:5 ω-3 EPA | 1.07 (0.99, 1.16) | 1.10 (1.00, 1.20) | 1.15 (1.05, 1.26)† |
| 22:5 ω-3 DPA | 0.66 (0.22, 2.01) | 0.70 (0.21, 2.30) | 1.46 (0.34, 6.29)† |
| 22:6 ω-3 DHA | 1.09 (0.95, 1.24) | 1.08 (0.94, 1.25) | 1.16 (0.96, 1.40)† |
| Long chain2 | 1.04 (0.98, 1.1) | 1.08 (1.04, 1.11) | 1.08 (1.01, 1.16)† |
| ω-3 PUFA3 | 1.05 (1.01, 1.08) | 1.05 (0.98, 1.12) | 1.07 (1.00, 1.16) |
| 18:2 ω-6 LA | 0.98 (0.95, 1.02) | 0.99 (0.95, 1.03) | 0.97 (0.92, 1.03) |
| 20:4 ω-6 AA | 1.04 (0.97, 1.12) | 1.07 (0.99, 1.16) | 1.05 (0.94, 1.18) |
| ω-6 PUFA | 0.99 (0.96, 1.02) | 1.01 (0.97, 1.04) | 1.00 (0.95, 1.05) |
| Ratio of ω-6 to ω-34 | 1.01 (0.93, 1.10) | 1.02 (0.92, 1.12) | 0.98 (0.84, 1.13)† |
| Ratio of LA to ALA5 | 1.00 (0.97, 1.02) | 1.00 (0.97, 1.02) | 1.00 (0.97, 1.04)† |
| Total PUFA | 1.00 (0.97, 1.03) | 1.01 (0.98, 1.05) | 1.01 (0.97, 1.06) |
AA, arachidonic acid; ALA, alpha linolenic acid; DHA, decosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; LA, linoleic acid, IQR, interquartile range (from 25th to 75th); PUFA, polyunsaturated fatty acids; RR, risk ratio
Bold values represent the following: P = 0.03 for ALA and clinical pregnancy. P = 0.04 for EPA and clinical pregnancy. P < 0.0001 for long chain and clinical pregnancy. P = 0.009 for ω-3 PUFA and implantation.
1Adjusted for age, BMI, smoking status, moderate-to-vigorous physical activity, use of multivitamins and history of live birth.
2Sum of EPA, DPA and DHA.
3Sum of ALA, EPA, DPA and DHA.
4Additional adjusted for ω-6 and ω-3 PUFA concentrations.
5Additional adjusted for LA and ALA concentrations.
†Modified Poisson model was used to estimate RR when GEE log bionomial models did not converge.