Table 2.

Fly Ortholog Genes Tested for Hypoxia Tolerance. Eclosion Rate (%) of the F1 Progeny from the “RNAi-line X da-Gal4” at 5% and 21% O₂.

Candidate Region	Human Gene	Fly Symbol	Fly Line	Fly_Chr	Eclosion at 5% O2	Eclosion at 21% O2
2	SGK3	S6k	41,702	3L	High	High
			57,016	3L	NS	High
		Akt1	31,701	3R	Lethal	Lethal
	C8orf44-SGK3		33,615	3R	Lethal	Lethal
		CG8726	35,281	2R	High	High
			57,230	2R	High	High
		Snx16	38,992	2R	High	High
	PPP1R42	dtr	25,812	2L	NS	High
	COPS5	CSN5	28,732	3R	High	Low
			42,781	3R	High	Low
	TCF24	HLH54F	28,698	2R	High	High
4	PRDM1	Blimp-1	36,634	3L	High	High
			57,479	3L	High	High
6	IFT122	Oseg1	51,904	3L	High	High
7	ZNF492	CG15269	51,506	2L	NS	High
	ZNF492, ZNF99	crol	41,669	2L	NS	High

High, in 21% O₂, “High” indicates higher eclosion rate of F1 progeny (from RNAi-line × da-Gal4) and in 5% O₂, “High” indicates significantly higher eclosion rate when compared with all four controls, that is, RNAi-line and the three background controls (w1118, da-Gal4, y¹v¹) kept under similar condition and therefore indicates hypoxia tolerance; Lethal, embryonic lethal or early larval stage lethal; NS, not significant between F1 progeny and controls.