Table 2.
Apparent diffusion coefficient values in clinical responders and non-responders
| Clinical responders | Clinical non- responders | P- values | |
|---|---|---|---|
| ADC pretreatment | 897 (189) | 849 (146) | 0.90 |
| ADC post-treatment | 675 (310) | 905 (351) | 0.097 |
| ΔADC | +139 (426) | −102 (426) | 0.33 |
| nADC pretreatment | 1.61 (0.60) | 1.65 (0.49) | 0.77 |
| nADC post-treatment | 1.39 (0.44) | 1.79 (0.31) | <0.01 |
| ΔnADC | +0.21 (0.27) | −0.12 (0.51) | 0.089 |
Median (interquartile range) nADC, uncorrected ADC, ΔnADC and ΔADC values are shown for responding and non-responding groups. The two groups were compared using the Mann–Whitney–Wilcoxon test; P-values are shown in the right-hand column. Positive ΔnADC and ΔADC values represent an improvement in inflammation; negative values represent a worsening of inflammation. ADC: apparent diffusion coefficient; nADC: normalized apparent diffusion coefficient; ΔADC: change in ADC after therapy; ΔnADC: change in nADC after therapy.