Fig. 2.

Macrophages infiltrate the DRG in a model of OA

(A) Unilateral intra-articular monosodium iodoacetate (MIA) injections in rats significantly increased the number of CD68⁺ macrophages in the lumbar DRG compared with the contralateral knee or vehicle injected rats at 4 weeks after injections (n = 6). (B) Exemplar images of the DRGs innervating the affected knee (ipsi) or the contral lateral knee (contra). Scale bar is 50 μm. Data are presented as mean and s.e.m. ***P < 0.001: statistical analyses were performed by two-way analysis of variance with the Bonferroni post hoc test.