Table 1.

PMP-encapsulated miRNAs and associated roles in cancer

miRNA	Role	Cell Type	Reference
miR-223	Suppression of FBXW7 and EFNA1, possibly resulting in apoptosis	HUVEC (endothelial)	(9, 36)
miR-223	Suppression of EPB41L3, leading to increased invasiveness	Lung cancer cells	(37)
miR-126-3p	Increased phagocytic phenotype	Primary human macrophages	(38)
miR-183	Suppress natural killer cell activation, possibly via silencing of DAP12	Natural killer cells	(39, 40)
miR-24	Mitochondrial dysfunction and tumor cell apoptosis, leading to suppression of tumor growth	Lung and colon cancer cells	(12)

miRNAs transferred from PMPs to cancer-associated cells are shown, with target cell type and cellular effects.