Table 4.

DEGs associated with metabolic disease

SHHF				Diabetes 1
Expr Log Ratio	Symbol	Location	Type(s)	Expr Log Ratio	Symbol	Location	Type(s)
–0.99	AGER	Plasma Membrane	Transmembrane receptor	1.136	ABAT	Cytoplasm	Enzyme
–1.454	ARSA	Cytoplasm	Enzyme	–0.602	ABCC8	Plasma Membrane	Transporter
1.534	ARSB	Cytoplasm	Enzyme	0.92	ABCG8	Plasma Membrane	Transporter
–1.764	C1S	Extracellular Space	Peptidase	0.629	ACAA2	Cytoplasm	Enzyme
–1.194	CXCL16	Extracellular Space	Cytokine	–0.776	ACAT2	Cytoplasm	Enzyme
–1.621	DCX	Cytoplasm	Other	–0.697	ADAM10	Plasma Membrane	Peptidase
–1.697	LIG1	Nucleus	Enzyme	–1.219	ADRA1B	Plasma Membrane	G-protein coupled receptor
–1.204	NAT8B	Cytoplasm	Enzyme	–3.176	ADRA1D	Plasma Membrane	G-protein coupled receptor
–1.234	PDK1	Cytoplasm	Kinase	–0.691	AKT1	Cytoplasm	Kinase
1.444	PIK3IP1	Cytoplasm	Other	–1.784	ALDH1A1	Cytoplasm	Enzyme
–1.668	POLB	Nucleus	Enzyme	–1.459	ALDH1L1	Cytoplasm	Enzyme
–1.381	PRNP	Plasma Membrane	Other	2.492	ALOX15	Cytoplasm	Enzyme
–1.427	PSEN1	Plasma Membrane	Peptidase	2.875	AMY2B	Extracellular Space	Enzyme
1.257	PTGS1	Cytoplasm	Enzyme	–1.363	APLN	Extracellular Space	Other
–1.237	SNRNP70	Nucleus	Other	–1.284	APOBEC1	Cytoplasm	Enzyme
1.267	SV2A	Cytoplasm	Transporter	–2.127	ARG1	Cytoplasm	Enzyme
–2.219	TUBA1C	Cytoplasm	Other	–0.711	ATP1A2	Plasma Membrane	Transporter
–1.378	UQCC2	Cytoplasm	Other	2.899	ATP1A4	Plasma Membrane	Transporter
				–1.124	ATP7A	Plasma Membrane	Transporter
				–2.395	AVPR2	Plasma Membrane	G-protein coupled receptor
				1.312	BCL2L1	Cytoplasm	Other
				0.848	BMP2	Extracellular Space	Growth factor
				1.046	BRCA1	Nucleus	Transcription regulator
				–0.927	CA4	Plasma Membrane	Enzyme
				1.356	CACNA1B	Plasma Membrane	Ion channel
				1.014	CACNA1S	Plasma Membrane	Ion channel
				–2.783	CASP8	Nucleus	Peptidase
				0.704	CAT	Cytoplasm	Enzyme
				–0.717	CAV1	Plasma Membrane	Transmembrane receptor
				0.795	CBLB	Nucleus	Enzyme
				0.951	Ccl2	Extracellular Space	Cytokine
				–0.861	CCNB1	Cytoplasm	Kinase
				–1.161	CCND1	Nucleus	Transcription regulator
				–1.261	CCND2	Nucleus	Other
				–1.099	CD44	Plasma Membrane	Other
				0.953	CD55	Plasma Membrane	Other
				–1.914	CDKN2B	Nucleus	Transcription regulator
				0.879	CEBPD	Nucleus	Transcription regulator
				–1.19	CEL	Extracellular Space	Enzyme
				–1.443	CHRNA5	Plasma Membrane	Transmembrane receptor
				2.434	CHRNB1	Plasma Membrane	Transmembrane receptor
				3.049	CNR1	Plasma Membrane	G-protein coupled receptor
				–1.606	COL18A1	Extracellular Space	Other
				–1.411	COL1A1	Extracellular Space	Other
				–1.683	COL1A2	Extracellular Space	Other
				–1.979	COL3A1	Extracellular Space	Other
				–0.757	COL4A1	Extracellular Space	Other
				–0.879	COL4A2	Extracellular Space	Other
				–1.037	COL5A1	Extracellular Space	Other
				–0.883	COL5A2	Extracellular Space	Other
				–1.291	COL5A3	Extracellular Space	Other
				–0.693	COL6A1	Extracellular Space	Other
				–1.028	COL6A3	Extracellular Space	Other
				–1.023	COL8A1	Extracellular Space	Other
				0.586	CPT1A	Cytoplasm	Enzyme
				1.683	CRP	Extracellular Space	Other
				0.823	CST3	Extracellular Space	Other
				–2.373	CTSK	Cytoplasm	Peptidase
				–1.26	CXCL12	Extracellular Space	Cytokine
				–0.965	CYP11A1	Cytoplasm	Enzyme
				2.541	CYP2E1	Cytoplasm	Enzyme
				–1.687	CYP7B1	Cytoplasm	Enzyme
				–0.808	Dclk1	Cytoplasm	Kinase
				1.204	DECR1	Cytoplasm	Enzyme
				0.926	DKK3	Extracellular Space	Cytokine
				–1.807	DPP4	Plasma Membrane	Peptidase
				1.335	DRD4	Plasma Membrane	G-protein coupled receptor
				–0.918	EIF2AK2	Cytoplasm	Kinase
				1.828	EIF4EBP1	Cytoplasm	Translation regulator
				–0.766	EPHA4	Plasma Membrane	Kinase
				1.681	FABP1	Cytoplasm	Transporter
				–0.902	FABP5	Cytoplasm	Transporter
				–1.589	FBN1	Extracellular Space	Other
				–1.834	FBN2	Extracellular Space	Other
				0.68	FDFT1	Cytoplasm	Enzyme
				–0.97	FLNA	Cytoplasm	Other
				–0.801	FYN	Plasma Membrane	Kinase
				3.723	GAL	Extracellular Space	Other
				–1.286	GAP43	Plasma Membrane	Other
				1.627	GCKR	Nucleus	Other
				1.926	GDF15	Extracellular Space	Growth factor
				–0.697	GFM1	Cytoplasm	Translation regulator
				1.799	GLRB	Plasma Membrane	Ion channel
				–1.371	GPD2	Cytoplasm	Enzyme
				1.401	GPNMB	Plasma Membrane	Enzyme
				0.725	GUCY1A3	Cytoplasm	Enzyme
				0.855	HADHA	Cytoplasm	Enzyme
				0.593	HADHB	Cytoplasm	Enzyme
				1.203	HBG2	Cytoplasm	Other
				–1.033	HK2	Cytoplasm	Kinase
				0.846	HMGCL	Cytoplasm	Enzyme
				–0.703	HMGCR	Cytoplasm	Enzyme
				3.441	HMGCS2	Cytoplasm	Enzyme
				–1.702	HOMER1	Plasma Membrane	Other
				1.727	HP	Extracellular Space	Peptidase
				–1.439	HRH1	Plasma Membrane	G-protein coupled receptor
				3.249	HSPA1L	Cytoplasm	Other
				–0.714	HSPB1	Cytoplasm	Other
				1.882	HTR1D	Plasma Membrane	G-protein coupled receptor
				0.894	ID1	Nucleus	Transcription regulator
				–0.657	IGF1	Extracellular Space	Growth factor
				0.675	IGF1R	Plasma Membrane	Transmembrane receptor
				1.624	IGFBP3	Extracellular Space	Other
				–2.072	IGFBP5	Extracellular Space	Other
				0.664	IL1R1	Plasma Membrane	Transmembrane receptor
				1.38	INSIG1	Cytoplasm	Other
				0.95	INSR	Plasma Membrane	Kinase
				–1.237	KCNAB3	Plasma Membrane	Ion channel
				–0.611	KCNJ11	Plasma Membrane	Ion channel
				0.764	KCNK3	Plasma Membrane	Ion channel
				1.819	KCTD16	Plasma Membrane	Other
				1.063	KLF10	Nucleus	Transcription regulator
				–0.613	KRAS	Cytoplasm	Enzyme
				2.749	LEPR	Plasma Membrane	Transmembrane receptor
				–0.69	LIMS1	Plasma Membrane	Other
				1.168	LIPC	Extracellular Space	Enzyme
				0.887	LRP8	Plasma Membrane	Transmembrane receptor
				–1.079	MAGI3	Cytoplasm	Kinase
				–1.167	MAOB	Cytoplasm	Enzyme
				–0.87	MEOX2	Nucleus	Transcription regulator
				–0.634	MGP	Extracellular Space	Other
				1.685	MS4A6A	Other	Other
				–1.838	MSTN	Extracellular Space	Growth factor
				2.404	NEFH	Cytoplasm	Other
				–2.808	NOS2	Cytoplasm	Enzyme
				0.816	NOTCH4	Plasma Membrane	Transcription regulator
				–0.977	NRAS	Plasma Membrane	Enzyme
				1.836	NTRK1	Plasma Membrane	Kinase
				2.42	OLR1	Plasma Membrane	Transmembrane receptor
				–1.059	OPRD1	Plasma Membrane	G-protein coupled receptor
				–1.268	OXCT1	Cytoplasm	Enzyme
				2.329	PAK1	Cytoplasm	Kinase
				0.7	PECAM1	Plasma Membrane	Other
				1.068	PIK3IP1	Cytoplasm	Other
				2.175	PKLR	Cytoplasm	Kinase
				–2.188	PLPP3	Plasma Membrane	Phosphatase
				0.697	POR	Cytoplasm	Enzyme
				–0.754	PPT2	Cytoplasm	Enzyme
				–0.61	PRKCA	Cytoplasm	Kinase
				–0.713	PRKCB	Cytoplasm	Kinase
				0.894	PSMD8	Cytoplasm	Other
				–1.882	PTGIS	Cytoplasm	Enzyme
				–1.791	QPCT	Cytoplasm	Enzyme
				–1.546	RAMP3	Plasma Membrane	Transporter
				–3.845	RET	Plasma Membrane	Kinase
				–0.767	S100A10	Cytoplasm	Other
				1.12	S100B	Cytoplasm	Other
				–0.842	SERPINE2	Extracellular Space	Other
				–0.833	SERPINF1	Extracellular Space	Other
				–0.586	SET	Nucleus	Phosphatase
				2.599	SLC12A1	Plasma Membrane	Transporter
				2.338	SLC12A3	Plasma Membrane	Transporter
				–1.043	SLC2A4	Plasma Membrane	Transporter
				1.018	SLC9A1	Plasma Membrane	Ion channel
				–0.882	SLCO2A1	Plasma Membrane	Transporter
				0.834	SORL1	Cytoplasm	Transporter
				1.193	SOX2	Nucleus	Transcription regulator
				0.936	SQSTM1	Cytoplasm	Transcription regulator
				2.28	SSTR2	Plasma Membrane	G-protein coupled receptor
				0.737	SSTR3	Plasma Membrane	G-protein coupled receptor
				2.067	STAR	Cytoplasm	Transporter
				0.641	TANGO2	Cytoplasm	Other
				1.49	TGFBR3	Plasma Membrane	Kinase
				–2.148	TGM1	Plasma Membrane	Enzyme
				–0.6	THBD	Plasma Membrane	Transmembrane receptor
				0.734	THRB	Nucleus	Ligand-dependent nuclear receptor
				0.828	TIMP3	Extracellular Space	Other
				–3.057	TLR7	Plasma Membrane	Transmembrane receptor
				–0.685	TMEM116	Other	Other
				0.736	TNNT2	Cytoplasm	Other
				–2.696	TOP2A	Nucleus	Enzyme
				–0.705	TP53	Nucleus	Transcription regulator
				2.123	TSPAN5	Plasma Membrane	Other
				–0.83	TUBA8	Cytoplasm	Other
				0.823	XDH	Cytoplasm	Enzyme

Green indicates the downregulated gene; red indicates the upregulated gene.