. 2018 Feb 28;2018:6328970. doi: 10.1155/2018/6328970

Table 2.

ARRIVE of the studies using flavonoids for the treatment of hepatocellular carcinoma in murine models.

	Reference																																		%
	[15]	[16]	[17]	[18]	[19]	[20]	[21]	[22]	[23]	[24]	[25]	[26]	[27]	[28]	[29]	[30]	[31]	[32]	[33]	[34]	[35]	[36]	[37]	[38]	[39]	[40]	[41]	[42]	[43]	[44]	[45]	[46]	[47]	[48]	%
Title
Accurate and concise a description of the content of the article	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Abstract
Summary of the background, objectives, methods, principal findings, and conclusions	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Introduction
Background	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Objectives	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Materials and methods
Ethical statement
Indicate the nature of the ethical review permissions, relevant licenses	X	X	X	X	X	X	X	X	X	X			X		X	X	X	X		X		X	X		X		X	X	X						64.71%
Study design
Number of experimental and control groups	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X	X	X	X						82.35%
Any steps taken to minimize the effects of subjective bias when allocating animals to treatment	X	X		X		X	X	X	X		X	X	X	X	X	X	X		X			X	X	X			X	X							58.82%
The experimental unit	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X										X								52.94%
Experimental procedures
Doses	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Method of administration	X	X	X		X	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X			X			X	X							64.71%
Time of day	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X		X															55.88%
Experimental animals
Origin of animal	X			X				X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	85.29%
Species	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Sex	X	X	X	X	X	X	X		X	X	X	X	X		X	X	X			X	X	X	X	X			X	X							64.71%
Developmental stage	X		X	X			X	X	X	X			X		X	X		X	X	X		X			X		X	X							50%
Weight	X	X			X	X		X		X	X	X	X	X	X	X	X			X		X	X		X		X								52.94%
Housing and husbandry
Housing	X	X	X		X			X		X				X	X		X		X				X		X		X	X							41.17%
Husbandry conditions	X		X	X	X	X		X		X		X		X	X		X		X			X	X		X		X	X							50%
Sample size
Specify the total number of animals used in each experiment	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X					X				X							61.76%
Explain how the number of animals was decided																																			0%
Allocating animals to experimental groups
How animals were allocated to experimental group (AZAR)	X	X	X	X		X	X	X	X		X	X			X	X	X	X	X	X			X	X				X							55.88%
Experimental outcomes
Clearly define the primary and secondary experimental outcomes assessed	X		X		X		X					X		X	X		X	X	X	X	X		X	X			X	X							47.05%
Statistical methods
Provide details of the statistical methods used for each analysis	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X			X	X			X	X							70.58%
Specify the unit of analysis for each dataset	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X			X	X			X	X							70.58%
Describe any methods used to assess whether the data met the assumptions of the statistical approach		X							X			X				X	X	X	X	X			X	X			X	X							35.29%
Results
Baseline data
For each experimental group, report relevant characteristics and health status of animals before treatment or testing	X		X					X							X								X												14.70%
Numbers analyzed
Report the number of animals in each group included in each analysis	X	X			X		X		X	X			X	X	X		X	X	X				X	X			X								44.11%
If any animals or data were not included in the analysis, explain why																																			0%
Outcomes and estimation
Report the results for each analysis carried out	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Adverse events
Give details of all important adverse events in each experimental group																								X											2.94%
Describe any modifications to the experimental protocols made to reduce adverse events																	X																		2.94%
Discussion
Interpretation/ scientific implications
Interpret the results, taking into account the study objectives and hypotheses, current theory, and other relevant studies in the literature	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	100%
Comment on the study limitations including any potential sources of bias																								X											2.94%
Generalizability/ translation
Comment on whether and how the findings of this study are likely to translate to other species or systems, including any relevance to human biology						X	X			X			X												X		X								17.64%
Funding
List all funding sources	X	X	X	X		X	X	X	X			X	X	X	X		X	X	X	X	X	X	X	X	X			X	X		X	X			73.52%

%	80%	68.57%	68.57%	62.85%	62.85%	65.71%	68.57%	71.42%	68.57%	71.42%	57.14%	68.57%	68.57%	65.71%	80.00%	65.71%	80.00%	62.85%	62.85%	65.71%	40.00%	45.71%	68.57%	65.71%	48.57%	28.57%	71.42%	68.57%	34.28%	25.71%	28.57%	28.57%	25.71%	25.71%