Table 2.
Outcome data from included studies
| First author, year (site) [reference] | Number of participants (total/I/C) | Survival to discharge (I vs C) | Survival of those with shockable rhythm (I vs C) | Temperature at hospital arrival (I vs C) | Pulmonary oedema (I vs C) | Re-arrest (I vs C) | Mean pre-hospital volume infused (ml) | Favourable neurological outcome (I vs C) | Survival at hospital arrival (I vs C) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bernard, 2002 (Australia) [6] | 77/43/34 | 21 (49%) | 11 (32%) | N/A | N/A | 35.0 | 35.5 | N/A | N/A | N/A | N/A | N/A | 21 (49%) | 9 (26%) | N/A | N/A |
| Bernard, 2010 (Australia) [17] | 234/118/116 | 56 (47%) | 62 (53%) | N/A | N/A | 34.6 | 35.4 | 0 | 0 | 0 | 0 | 1900 | 56 (48%) | 61 (53%) | N/A | N/A |
| Bernard, 2012 (Australia) [18] | 163/82/81 | 11 (13%) | 7 (9%) | N/A | N/A | 34.4 | 35.7 | 0 | 0 | N/A | N/A | 1500 | 10 (12%) | 7 (10%) | 75 (91%) | 74 (91%) |
| Bernard, 2016 (Australia) [11] | 1198/618/580 | 63 (10%) | 66 (11%) | 55 (19%) | 62 (23%) | 34.7 | 35.4 | 62 (10%) | 26 (45%) | N/A | N/A | 1200 | 63 (10%) | 63 (11%) | 304 (49%) | 317 (55%) |
| Castren, 2010 (multi-site) [23] | 200/96/104 | 14 (15%) | 13 (13%) | 10 (37%) | 10 (33%) | 34.2 | 35.5 | 0 | 0 | 3 (3%) | 2 (2%) | N/A | 11 (11%) | 9 (9%) | 32 (33%) | 42 (41%) |
| Debaty, 2014 (France) [22] | 245/123/122 | 7 (6%) | 5 (4%) | N/A | N/A | 33.9 | 35 | 7 (6%) | 8 (7%) | N/A | N/A | 1000 | 7 (6%) | 4 (3%) | 41 (33%) | 36 (30%) |
| Kamarainen, 2009 (Finland) [21] | 37/19/18 | 11 (58%) | 10 (56%) | N/A | N/A | 34.1 | 35.2 | 0 | 0 | 2 (11%) | 3 (17%) | 2370 | 8 (42%) | 8 (44%) | N/A | N/A |
| Kim, 2007 (United States) [20] | 125/63/62 | 21 (67%) | 18 (71%) | 19 (66%) | 10 (45%) | 34.7 | 35.7 | 24 (38%) | 27 (44%) | 15 (24%) | 13 (21%) | 1236 | 19 (30%) | 16 (26%) | 49 (78%) | 48 (77%) |
| Kim, 2014 (United States) [19] | 1359/688/671 | 259 (38%) | 249 (37%) | 183 (63%) | 187 (64%) | 34.8 | 35.8 | 256 (37%) | 184 (27%) | 176 (26%) | 138 (21%) | 1435 | 231 (34%) | 225 (33%) | 679 (99%) | 660 (98%) |
| Scales, 2017 (Canada) [12] | 582/279/303 | 92 (33%) | 98 (31%) | 79 (64%) | 74 (55%) | 35.1 | 35.2 | 33 (12%) | 54 (18%) | 21 (8%) | 25 (8%) | 640 | 82 (29%) | 76 (26%) | 250 (90%) | 258 (85%) |
I Intervention (pre-hospital therapeutic hypothermia), C Comparator