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Genomic organization of CAXII gene. A. The Homo sapiens gene contains 13 exons whereas the mouse gene (B) has 11 exons (38). Other mouse CA genes contain different numbers of exons; however, the functional domains are highly conserved (2). The amino acid sequences for Homo sapiens (Gene ID 771) and Mus musculus (Gene ID 76459) shown below were obtained from the Gene database in NCBI using the Ensembl Genome Browser (release 87).
