Table 3.
Oxidative stress and endothelial dysfunction parameters depending on thrombomodulin concentration in the investigated group of 59 patients.
| Parameter | Thrombomodulin | p value∗ | |
|---|---|---|---|
| <2xULN (n = 26) | ≥2xULN (n = 33) | ||
| vWF (%) | 87.8 (78.8; 93.3) | 90.2 (82.8; 96.7) | 0.521 |
| Carbonyl groups (nmol/mg) | 1.18 (0.61; 1.89) | 1.36 (0.82; 2.17) | 0.634 |
| ADMA (μmol/l) | 0.94 (0.75; 1.16) | 1.23 (0.90; 1.40) | 0.029 |
| BNP (pg/ml) | 4.43 (1.00; 15.39) | 15.63 (5.88; 24.23) | 0.021 |
| oxLDL (U/l) | 80.6 (67.4; 91.9) | 88.6 (78.7; 106.9) | 0.033 |
| hsCRP (ng/ml) | 373.2 (132.6; 736.1) | 310.7 (145.6; 878.1) | 0.535 |
| ICAM-1 (ng/ml) | 373.2 (132.6; 736.1) | 323.6 (290.3; 384.4) | 0.977 |
| Fibrinogen (g/l) | 3.5 (2.5; 4.4) | 3.3 (2.4; 4.4) | 0.856 |
Values presented as median (25th–75th percentile). ∗Mann–Whitney U test. ULN: upper limit of normal; vWF: von Willebrand factor; ADMA: asymmetric dimethylarginine; BNP: brain natriuretic peptide; oxLDL: oxidized low-density lipoprotein; hsCRP: high sensitive C-reactive protein; ICAM-1: intercellular adhesion molecule-1.