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. 2018 Mar 14;25:24. doi: 10.1186/s12929-018-0419-3

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The expression of inflammatory markers in macrophages. THP-1 cells were treated with1 μg/mL lipopolysaccharides (LPS) or 5 μg/mL full length adiponectin (ADN) for 18 h. a the relative mRNA expression of cox2. b the PGE2 secretion to the culture medium. c the relative mRNA expression of IL-8. d the IL-8 secretion to the culture medium. e the relative mRNA expression of TNF-α. f the TNF-α secretion to the culture medium. g the relative mRNA expression of IL-1. h the IL-1 secretion to the culture medium. i the relative mRNA expression of IL-6. j the IL-6 secretion to the culture medium. Data were analyzed by one-way ANOVA with mean separation using Tukey’s test. Each bar represents the mean ± SEM; a value of p ≤ 0.05 was considered significant. * means p ≤ 0.05, ** means p ≤ 0.005, *** means p ≤ 0.0005, **** means p ≤ 0.0001