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. 2017 Nov 6;37(8):1086–1094. doi: 10.1038/onc.2017.383

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DHRS2 stabilized P53 and decreased p38MAPK phosphorylation. (a) The protein levels of p-P53(ser15) and p-Rb(ser795) were determined in DHRS2-V1 and DHRS2-V2-transfected KYSE510 and KYSE30 cells compared with vector control cells. (b) The protein levels of p-P53(ser15) and p-Rb(ser795) were determined in DHRS2 knock-down KYSE180 and HKESC1 cells. Tubulin was set as loading control. (c) The protein levels of p-p38MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2), MMP2, E-cadherin and β-catenin were determined in DHRS2-V1 and DHRS2-V2-transfected KYSE510 and KYSE30 cells compared with vector control cells. (d) The protein levels of p-p38MAPK, ERK1/2, MMP2, E-cadherin and β-catenin were determined in DHRS2 knock-down KYSE180 and HKESC1 cells. GAPDH was set as loading control.