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. 2018 Mar 13;16:61. doi: 10.1186/s12967-018-1439-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Kinetics of cytokine production or CD107a expression in T_EM cells. a Kinetics of CD107a expression (degranulation marker) or cytokine production by CVD1208S (left panels) and placebo (right panels) recipients in CD8 T_EM cells. Filled triangles at the bottom indicate vaccination days. In the vaccinated group only the data of the individuals that showed increase in CD107a or cytokine expression relative to pre-vaccination (Fig. 3c) were used to generate these graphs. In the placebo group all the available data was used. The data is presented as the difference between the percentage of B-LCL cells loaded with IpaB and unstimulated B-LCL cells [LCL-IpaB − LCL (%)]. b Similar data from CD4 T_EM cells. Arithmetic mean ± SD are displayed in the plots