Table 1.
Overview of migration signals for dental pulp stem cells (DPSC) with their corresponding receptors, and their specific roles in dentin pulp regeneration and inflammation.
| Chemotactic Molecule | Receptor | Inflammation | Regeneration | Role | Reference |
|---|---|---|---|---|---|
| HGF | c-Met | x | Recruitment of DPSC | [13] | |
| FGF-2 | FGF receptors 1 and 2 | x | Recruitment of DPSC and pulp cell proliferation | [9,16,17] | |
| TGFβ-1 | TGF-β1 receptors I and II | x | Recruitment of DPSC and odontoblastic differentiation | [9,16,18,19] | |
| MCP-1 | CCR2 | x | Recruitment of DPSC and stem cell homing* | [10,20] | |
| CXCL14 | C-X-C chemokine receptor type 4 (CXCR4) | x | x | Recruitment of DPSC and mediator of immune cell migration* | [10,21] |
| G-CSF | G-CSF receptor | x | x | DPSC mobilization and anti-inflammatory properties | [12,22,23] |
| S1P | S1P receptor 1–3 | x | x | Pleiotropic actions including recruitment of DPSC and inflammatory effects* | [9,24,25] |
| SDF-1 | CXCR4 | x | Recruitment of DPSC and stem cell homing* | [11,20,26,27] | |
| C5a | C5a receptor | x | x | Recruitment of DPCS and inflammatory cells* | [8,28,29] |
| HMGB-1 | receptor for advanced glycation end products (RAGE) | x | x | Recruitment of DPCS and production of inflammatory cytokines* | [14,30] |
* Demonstrated outside dental pulp context.