Table 2.
Characteristics of study participants and association of baseline biomarker concentrations with covariates for the whole cohort
| Covariates | Comparators (n=406) | Cases (n=194) | Biomarker associations with covariates* |
|---|---|---|---|
| Age, mean years (SD) | 61.3 (8.9) | 62.0 (8.8) | sCOMP, sHA, sMMP3, uC2C-HUSA, uC1, 2C, uCTXII |
| Sex, n (%) female | 243 (60%) | 110 (57%) | sC1, 2C, sCS846, sCTXI, s+uNTXI, sMMP3, uCol2-1 NO2, uC1, 2C, uC2C-HUSA, uCTXII, uCTXIα, uCTXIβ |
| BMI, mean kg/m2 (SD) | 30.7 (4.8) | 30.7 (4.8) | sCTXI, sMMP3, sPIIANP, uNTXI, uCTXIα |
| History of knee injury, n (%) yes | 145 (36%) | 68 (35%) | |
| Baseline knee Kellgren-Lawrence grade, n (%) | |||
| KL1 | 51 (13%) | 24 (12%) | |
| KL2 | 222 (55%) | 84 (43%) | |
| KL3 | 133 (33%) | 86 (44%) | |
| White race, n (%) | 320 (79%) | 1 55 (80%) | sC1, 2C, s+uCol2-1 NO2, sCTXI, sHA, uC2C-HUSA |
| Baseline use of pain medication, n (%) yes | 114 (28%) | 63 (32%) | sCPII, uCol2-1 NO2, uCTXII, uNTXI, uCTXIα |
| Baseline WOMAC pain score, mean (SD) | 13.0 (16.7) | 10.2 (13.0) | sPIIANP, uCTXII |
| Baseline joint space width, mean mm (SD) | 3.9 (1.1) | 3.8 (1.4) | sHA, uC2C-HUSA |
*
Detailed results of associations of biomarkers with covariates are provided in online supplementary table S2.
WOMAC, Western Ontario and McMaster Universities Arthritis Index.