Table 2.
Summary of gene expression in adipose tissue and liver in SHR and SHROB after treatment with palm11-PrRP31
| Tissue | Gene | SHROB vs SHR | SHR palm11-PrRP31 vs vehicle | SHROB palm11-PrRP31 vs vehicle |
|---|---|---|---|---|
| SCAT | Acaca | ↑*** | – | ↓ |
| Glut4 | ↑** | – | – | |
| Lep | ↑*** | ↓* | ↓ | |
| Lpl | ↑* | ↓ | ↓ | |
| Pparγ | ↑** | ↑ | ↓ | |
| Scd1 | ↑*** | ↓ | ↓ | |
| IPAT | Irs1 | – | ↑* | ↑*** |
| Irs2 | ↓** | ↑ | ↑*** | |
| Srebf1 | ↓* | ↑** | ↑* | |
| BAT | Glut4 | ↑*** | ↑* | ↑ |
| UCP-1 | ↓*** | ↑ | – | |
| Liver | Acaca | ↑* | ↑ | ↓ |
| Fasn | ↑** | – | ↓ | |
| Pparα | ↑** | ↓ | ↓* | |
| Pparγ | ↑*** | ↑ | ↓ |
Statistical analysis was performed by unpaired t-test
SCAT subcutaneous adipose tissue, IPAT intraperitoneal adipose tissue, BAT brown adipose tissue, Acaca acetyl-CoA carboxylase 1, Glut4 glucose transporter type 4, Lep leptin, Lpl lipoprotein lipase, Pparγ peroxisome proliferator-activated receptor γ, Scd1 stearoyl-CoA desaturase-1, Irs1,2 insulin receptor substrate 1,2, Srebf1 sterol regulatory element-binding protein 1, UCP-1 uncoupling protein 1, Fasn fatty acid synthase, ↓ decrease, ↑ increase Significance is *P < 0.05, **P < 0.01, ***P < 0.001 vs the respective vehicle-treated control group (n = 8). The expression of particular genes was normalized to beta-2-microglobulin (B2m)