Table 3. Cox regression on 11 SNPs in the discovery, validation and combined dataset.
| SNP | Discovery | Validation | Combined | |||
|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| rs113988120 | 3.06 (2.10-4.47) | 6.40E-09 | 1.44 (1.02-2.02) | 0.037 | 1.79 (1.40-2.29) | 2.70E-06 |
| rs4780973 | 0.77 (0.68-0.86) | 2.60E-06 | 0.90 (0.79-1.02) | 0.11 | 0.82 (0.76-0.89) | 4.40E-06 |
| rs9815265 | 0.75 (0.68-0.83) | 6.70E-08 | 1.02 (0.92-1.14) | 0.70 | 0.87 (0.81-0.94) | 2.70E-04 |
| rs6438217 | 1.40 (1.23-1.59) | 4.40E-07 | 1.01 (0.86-1.17) | 0.94 | 1.19 (1.08-1.31) | 5.80E-04 |
| rs12638565 | 1.35 (1.19-1.52) | 1.80E-06 | 1.04 (0.92-1.17) | 0.57 | 1.14 (1.05-1.24) | 2.10E-03 |
| rs4568126 | 0.77 (0.70-0.85) | 3.10E-07 | 0.97 (0.87-1.09) | 0.64 | 0.85 (0.79-0.91) | 6.10E-06 |
| rs12186112 | 0.78 (0.70-0.86) | 6.00E-07 | 0.99 (0.88-1.12) | 0.92 | 0.87 (0.81-0.94) | 3.60E-04 |
| rs13060627 | 0.79 (0.70-0.88) | 4.50E-05 | 0.94 (0.82-1.07) | 0.33 | 0.85 (0.78-0.93) | 2.40E-04 |
| rs923936 | 0.79 (0.70-0.88) | 5.90E-05 | 1.08 (0.94-1.24) | 0.27 | 0.88 (0.82-0.94) | 1.30E-04 |
| rs13173842 | 1.27 (1.14-1.42) | 1.30E-05 | 0.97 (0.86-1.10) | 0.61 | 1.11 (1.02-1.20) | 1.40E-02 |
| rs10926274 | 0.83 (0.75-0.91) | 2.20E-04 | 1.02 (0.91-1.14) | 0.72 | 0.91 (0.84-0.98) | 1.50E-02 |
Cox regression analysis was under additive genetic model with adjustment for age, sex, tumor stage, resection, and chemotherapy in validation and combined datasets and with additional adjustment for five principal components accounting for population structure in the discovery set.