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. Author manuscript; available in PMC: 2018 Mar 14.
Published in final edited form as: Nat Rev Rheumatol. 2016 Mar 24;12(5):259–268. doi: 10.1038/nrrheum.2015.179

Figure 3. Multi-layer model of pathogenic events leading to the development of MAS in the context of rheumatic diseases.

Figure 3

Genetic factors and the inflammatory milieu created by the underlying rheumatic disease act synergistically to reach the threshold for macrophage activation syndrome (MAS) in the presence of an infectious trigger.