Table 2.

Biomarker test characteristics and cut-off values for prediction of AKI

	Cut-off point	Sensitivity	Specificity	PPV	NPV	AUC	p > Chi-Square
TIMP-2*IGFBP-7 ((ng/mL)2/1000)
2 hour	1.03	0.59	0.71	0.43	0.82	0.60	0.33
6 hour	0.66	0.68	0.49	0.38	0.77	0.58	0.26
12 hour	0.78	0.69	0.69	0.50	0.83	0.71	0.002
24 hour	1.46	0.41	0.85	0.60	0.73	0.63	0.04
Urine NGAL (ng/mL)
2 hour	163.88	0.35	0.84	0.47	0.76	0.55	0.58
6 hour	58.85	0.72	0.43	0.35	0.78	0.51	0.77
12 hour	58.25	0.46	0.80	0.52	0.76	0.64	0.04
24 hour	34.03	0.62	0.79	0.61	0.79	0.71	0.003
Urine IL-18 (pg/mL)
2 hour	1587.7	0.91	0.15	0.31	0.80	0.47	0.72
6 hour	51.26	0.23	0.88	0.46	0.72	0.51	0.91
12 hour	72.74	0.46	0.68	0.41	0.73	0.50	0.66
24 hour	182.54	0.84	0.30	0.40	0.77	0.54	0.45
Urine KIM-1 (pg/mL)
2 hour	372.16	0.65	0.63	0.43	0.81	0.63	0.23
6 hour	137.37	0.85	0.53	0.44	0.89	0.66	0.03
12 hour	417.21	0.71	0.51	0.41	0.79	0.61	0.08
24 hour	529.57	0.84	0.41	0.44	0.82	0.60	0.18
Urine L-FABP (ng/mL)
2 hour	32.66	0.70	0.54	0.40	0.80	0.61	0.08
6 hour	109.30	0.65	0.52	0.38	0.77	0.57	0.22
12 hour	58.27	0.75	0.43	0.38	0.79	0.50	0.92
24 hour	14.60	0.48	0.75	0.52	0.72	0.60	0.16

Ng = nanograms, pg = picograms, mL = milliliter, PPV = positive predictive value, NPV = negative predictive value, AUC = area under the curve, TIMP-2*IGFBP-8 = tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7), NGAL = neutrophil gelatinase-associated lipocalin, IL-18 = interleukin-18, KIM-1 = kidney injury molecule 1, L-FABP = liver-type fatty acid-binding protein.