Table 3.

Unadjusted and adjusted models for biomarkers and other confounding factors related to an increase in serum milrinone concentration prior to the diagnosis of AKI

Variable	Odds Ratio (95% Confidence Interval)	p
Unadjusted
TIMP2-IGFBP-7 >0.78	2.72 (1.01–7.38)	0.04
KIM-1 >529.57	2.76 (1.06–7.17)	0.03
Multivariable Model (AUC=0.788)
TIMP-2*IGFBP-7 >0.78	2.29 (0.74–7.14)	0.15
KIM-1 >585.6	3.74 (1.22–11.47)	0.02
Prior surgery (Yes vs. No)	0.15 (0.05–0.47)	0.001
Circulatory arrest (Yes vs. No)	4.37 (1.16–16.48)	0.03
Peritoneal drain (Yes vs. No)	0.18 (0.05–0.6)	0.005

TIMP-2*IGFBP7 = tissue inhibitor metalloproteinase type 2 and insulin-like growth factor-binding protein type 7, KIM-1 = kidney injury molecule 1, AUC = area under the curve, AKI = acute kidney injury. Age, gender, and STAT score were included in the multivariable model but are not reported as they were not found to be independent predictors of an increase in serum milrinone concentrations prior to the diagnosis of AKI (all stages).