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. 2018 Mar 14;13(3):e0193731. doi: 10.1371/journal.pone.0193731

Table 3. Association between circulating ANGPTL levels and general medical status (n = 800).

A generalized linear model was used. All variables listed were included in the model. ANGPTL, Angiopoietin-like protein; β, regression coefficient; 95% CI, 95% confidence interval; P, probability; and CKD, chronic kidney disease.

log(ANGPTL3) log(ANGPTL4) log(ANGPTL8)
β 95%CI P β 95%CI P β 95%CI P
Age
    >53 0.066 (0.028, 0.104) 0.001 -0.087 (-0.128, -0.046) <.001 0.051 (0.003, 0.098) 0.038
    45–53 0.000 (-0.036, 0.036) 0.984 0.022 (-0.016, 0.061) 0.260 -0.022 (-0.067, 0.023) 0.336
    ≤44 - - - - - - - - -
Male gender -0.095 (-0.130, -0.059) <.001 0.148 0.110, 0.186) <.001 0.050 (0.006, 0.094) 0.027
Smoking 0.004 (-0.032, 0.040) 0.817 0.022 (-0.018, 0.059) 0.298 -0.023 (-0.069, 0.022) 0.306
Drinking -0.012 (-0.040, 0.017) 0.410 0.002 (-0.028, 0.033) 0.869 -0.032 (-0.069, 0.003) 0.076
Obesity -0.024 (-0.055, 0.008) 0.140 -0.002 (-0.036, 0.032) 0.915 0.088 (0.049, 0.128) <.001
Impaired glycometabolism 0.051 (-0.005, 0.106) 0.072 0.101 0.041, 0.160) <.001 -0.129 (-0.198, -0.059) <.001
Hypertension -0.016 (-0.048, 0.017) 0.350 0.000 (-0.035, 0.035) 0.994 0.009 (-0.032, 0.050) 0.653
Dyslipidemia -0.020 (-0.048, 0.008) 0.162 0.029 (-0.002, 0.059) 0.063 0.085 (0.050, 0.121) <.001
Hyperuricemia 0.006 (-0.034, 0.046) 0.760 0.018 (-0.025, 0.061) 0.408 0.044 (-0.007, 0.094) 0.090
Hepatic impairment 0.032 (0.001, 0.063) 0.040 0.037 0.004, 0.070) 0.028 0.029 (-0.010, 0.067) 0.146
CKD 0.001 (-0.037, 0.058) 0.672 0.026 (-0.024, 0.077) 0.308 0.029 (-0.031, 0.089) 0.343
Anemia 0.013 (-0.022, 0.048) 0.478 -0.016 (-0.055, 0.022) 0.401 0.004 (-0.040, 0.049) 0.850
Cardiac abnormality 0.034 (-0.081, 0.149) 0.560 -0.084 (-0.207, 0.040) 0.185 0.039 (-0.105, 0.183) 0.596
Inflammation 0.077 (0.018, 0.136) 0.011 -0.110 (-0.173, -0.046) <.001 -0.025 (-0.099, 0.049) 0.512