Table 2. Multivariate analysis of the difference between children with celiac disease (cases) and controls.
Amino acid levels are analyzed using a general linear model with age, sex and experimental effects as covariates. Nominal p-values are presented for diagnosis of celiac disease vs controls, for age of sampling and for sex. Mean levels are reported as concentrations in plasma (pmol/μl).
| Amino acid | CD vs. control | Age | Controls | CD |
|---|---|---|---|---|
| p-value | p-value | Mean pmol/μl | Mean pmol/μl | |
| Tryptophane | 0.004 | 0.01 | 43.8 | 45.9 |
| Taurine | 0.005 | 1.13E-03 | 86.9 | 99.6 |
| Glutamic Acid | 0.015 | 0.45 | 106.3 | 123.7 |
| Proline | 0.017 | 2.63E-10 | 160.9 | 156.2 |
| Ornithine | 0.017 | 1.28E-05 | 80.8 | 83.3 |
| Alanine | 0.045 | 7.60E-07 | 299.9 | 300.3 |
| Methionine | 0.048 | 4.87E-09 | 16.4 | 17.0 |
| Phenylalanine | 0.075 | 1.62E-11 | 48.3 | 47.7 |
| Glutamine | 0.136 | 0.10 | 515.4 | 486.8 |
| Aspartic Acid | 0.142 | 0.36 | 9.1 | 12.4 |
| Tyrosine | 0.147 | 8.21E-04 | 64.0 | 63.8 |
| Leucine | 0.156 | 5.90E-13 | 132.7 | 125.0 |
| Histidine | 0.158 | 5.82E-04 | 106.7 | 110.1 |
| Cysteine | 0.171 | 1.76E-07 | 13.7 | 14.7 |
| Serine | 0.275 | 0.91 | 139.9 | 146.4 |
| Valine | 0.485 | 3.97E-06 | 194.5 | 189.6 |
| Lysine | 0.562 | 1.82E-12 | 125.7 | 122.7 |
| Glycine | 0.57 | 0.62 | 216.2 | 223.6 |
| Threonine | 0.709 | 9.39E-07 | 93.9 | 93.4 |
| Citrulline | 0.799 | 7.21E-10 | 149.6 | 129.3 |
| Arginine | 0.847 | 3.00E-05 | 36.8 | 33.1 |
| Asparagine | 0.864 | 5.46E-04 | 54.1 | 54.8 |
| Isoleucine | 0.928 | 9.01E-11 | 60.3 | 54.5 |
CD = Celiac disease. Nominally significant p-values in the CD vs Control group are presented in bold.