Table 2. Effect of 1, 2, 3 and 10 mM of compounds (1), (2), (3) and (4) on hTS versus R163K-hTS % activity.
| Cpd. # Conc. | 1 mM | 3 mM | 10 mM | |
|---|---|---|---|---|
| % Activity Mean ± SD | ||||
| Cpd. (1) | hTS | 80.4 ± 5.20 | 0.25 ± 0.43 | 0.66 ± 1.22 |
| R163K-hTS | 99.9@ ± 1.80 | 57.4@ ± 3.90 | 0.39 ± 0.53 | |
| Cpd. (2) | hTS | 84.2 ± 5.25 | 34.2 ± 2.98 | 0.30 ± 0.58 |
| R163K-hTS | 94.3@ ±1.62 | 50.3@ ± 3.90 | -0.54 ± 0.90 | |
| Cpd. (3) | hTS | 76.9 ± 4.94 | 0.17 ± 0.86 | 0.96 ± 1.75 |
| R163K-hTS | 76.0 ± 4.21 | 27.0@ ± 4.49 | 0.19 ± 0.86 | |
| Cpd. (4) | hTS | 77.3 ±3.54 | 0.89 ± 0.42 | 0.26 ± 1.10 |
| R163K-hTS | 100.5@± 2.15 | 47.1@ ± 6.38 | -0.25 ± 1.15 | |
Values represent enzyme activity as % of control in presence of different concentrations of selected test compounds. The data are the means of 3 separate determinations.
@ Significant difference from hTS, at the same concentration, at p ≤ 0.05.