Fig. 1.

Known variants. a Genome size, known variant count in dbSNP, variant effect, and consequences of transcript variants. The red box contains the variant effects for the 20.1 M SNPs found in T5D. (All other zebrafish data refer to the reference genome and publically available data). b Allele frequency spectrum for common human variants. c Number of models per disease category stacked by organism (from https://monarchinitiative.org). d Number of phenotype-gene associations per species (from monarchinitiative.org)