Table 4.
Categories of CR-regulated genes in young and old mice
| Gene category | Young CR/old CR
|
|
|---|---|---|
| %* | Ratio† | |
| Stress response/chaperones | 80 | 4/5 |
| Energy metabolism/biosynthesis | 55 | 6/11 |
| Xenobiotic metabolism | 50 | 4/8 |
| Apoptosis/cell growth and survival | 44 | 4/9 |
| Intracellular signaling | 25 | 1/4 |
| Inflammatory response | 0 | 0/6 |
| Major urinary proteins | 0 | 0/4 |
| Cell cycle/DNA replication | 0 | 0/2 |
| Miscellaneous | 55 | 6/11 |
| Total | 42 | 25/60 |
*
The percentage of genes in each category that changed expression in young with respect to old CR mice.
†
The ratio between the number of genes that change expression in young and old CR mice.