Table 3.
Association of IGFBP-2 SNPs with Mini-Mental Status Exam (MMSE) scores and the ADNI Memory composite score
| SNP | MMSE | ADNI Memory Factor | ||||||
|---|---|---|---|---|---|---|---|---|
| Common Allele | Effect Allele | Beta | Beta P value | Common Allele | Effect Allele | Beta | Beta P value | |
| rs4619 AA vs GA + GG |
29.1 ± 1.55 | 24.9 ± 2.02 | −0.32 | P = 0.089 | 1.01 ± 0.59 | −0.14 ± 0.64 | −0.12 | P = 0.047 |
|
| ||||||||
| rs138105891 AA vs GA + GG |
28.5 ± 1.31 | 25.4 ± 0.57 | −0.21 | P = 0.044 | 0.95 ± 0.44 | 0.33 ± 0.39 | −0.30 | P = 0.068 |
|
| ||||||||
| rs41258845 CC vs GC + GG |
29.2 ± 1.17 | 25.6 ± 1.02 | −0.34 | P = 0.199 | 1.03 ± 0.67 | −0.04 ± 0.77 | −0.11 | P = 0.041 |
|
| ||||||||
| rs1065782 GG vs GA + AA |
27.2 ± 1.75 | 24.5 ± 1.09 | −0.17 | P = 0.441 | 1.10 ± 0.48 | −0.02 ± 0.58 | −0.22 | P = 0.052 |
Beta values represent the difference in the predicted value of either MMSE or the ADNI memory factor based on an increase from no risk allele, one risk allele, or two risk alleles.