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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Psychiatry Res. 2017 Sep 14;262:465–468. doi: 10.1016/j.psychres.2017.09.025

Figure 1. Long non-coding and endogenous retroviral RNA levels correlate with proinflammatory gene expression, and are responsive to proinflammatory stimuli.

Figure 1

A) RNA expression levels of TMEVPG1, NRON, HERV-W env and HERV-W gag are positively correlated with mRNA expression of IL-6 in PBMCs from the entire participant sample (2-tailed; n=33). RNA expression of HERV-W gag is positively correlated with mRNA expression of IFN-γ. Data points for participants with schizophrenia and controls are displayed as filled and hollow points, respectively. B) Fold change relative to vehicle of non-coding and endogenous retroviral transcript expression following IFN-γ and LPS treatment at 1, 8 and 24 hour time points in THP-1 cells (n=2). One-way ANOVA with Tukey’s post-hoc **p<0.01, *p<0.05