Table 1.
Demographic and Clinical Comparison of ET Cases and Controls
Variable | ET Cases | Controls | Significance |
---|---|---|---|
N | 45 | 35 | |
Age in years | 74.98 ± 6.16 | 73.26 ± 6.06 | 0.22a |
Male gender | 26 (57.8) | 10 (28.6) | 0.009b |
Right handed | 38 (84.4) | 31 (88.6) | 0.85c |
White race | 43 (95.6) | 32 (91.4) | 0.65c |
Married | 28 (62.2) | 22 (62.9) | 0.95b |
Education (years) | 17.9 ± 3.7 [18.0] | 18.2 ± 4.8 [17.5] | 0.87d |
Current smoker | 1 (2.2) | 1 (2.9) | 1.00c |
MoCA score | 27.5 ± 2.3 [28.0] | 28.2 ± 1.7 [28.0] | 0.22d |
Number of prescription medications | 3.5 ± 2.5 [3.0] | 3.2 ± 2.9 [3.0] | 0.40d |
Ethanol use <1 drink/week <1 drink/day 1 drink/day > 1 drink/day |
21 (46.7) 14 (31.1) 3 (6.7) 7 (15.6) |
20 (57.1) 6 (17.1) 5 (14.3) 4 (11.4) |
0.34b |
Total tremor score | 21.5 ± 4.1 [22.0] | 5.6 ± 2.3 [5.0] | <0.001d |
Neck or jaw tremor | 26 (57.8) | NA | NA |
Age of tremor onset in years | 41.5 ± 20.4 [47.5] | NA | NA |
Tremor duration in years | 34.0 ± 19.6 [30.0] | NA | NA |
Prescribed medication for tremor at some point | 29 (64.4) | NA | NA |
Left dentate volume (c.c.) | 1.37 ± 0.22 | 1.40 ± 0.21 | 0.42a |
Right dentate volume (c.c.) | 1.47 ± 0.24 | 1.49 ± 0.21 | 0.69a |
Left dentate GABA concentration (i.u.) | 1.68 ± 0.49 | 1.80 ± 0.53 | 0.69a |
Right dentate GABA concentration (i.u.) | 2.01 ± 0.45 | 1.86 ± 0.53 | 0.53a |
All values represent mean ± standard deviation or number (percentage).
c.c. = cubic centimeters, i.u. = institutional units, MoCA = Montreal Cognitive Assessment.
Student’s t test
Chi-square test
Fisher’s exact test
Mann-Whitney test