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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Feb 14;28(6):1024–1029. doi: 10.1016/j.bmcl.2018.02.027

Scheme 1.

Scheme 1

Synthesis of compounds 2–31. Reagents and conditions: (i) 3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid, NaOAc:AcOH (1:10),105 °C, 6–14 h, 47–87%; (ii) iodobenzene, Pd(PPh3)2Cl2, K2CO3, dioxane:H2O (3:1), 100 °C, overnight, 71–87%.