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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Feb 3;28(6):1101–1105. doi: 10.1016/j.bmcl.2018.01.069

Figure 4.

Figure 4

Comparison of inhibition potencies (IC50) of mutant versus recombinant wild-type(WT) thrombins by 2c (A) and 2i (B) at pH 7.4 and 25 °C. The IC50s were measured using Spectrozyme TH substrate hydrolysis assay, as described earlier.