Table 1.
Maternal and fetal characteristics at P14 and P18
| WT dams | BKCa −/− dams | ||||||
|---|---|---|---|---|---|---|---|
| P14 (10) | P18 (11) | P P14 vs. P18 | P14 (5) | P18 (6) | P P14 vs. P18 | P WT vs. BKCa −/− | |
| Maternal heart rate (beats min−1) | 555 ± 8 | 564 ± 6 | NS | 555 ± 15 | 575 ± 10 | NS | NS |
| Relative wall thickness | 0.5 ± 0.02 | 0.49 ± 0.02 | NS | 0.53 ± 0.02 | 0.51 ± 0.03 | NS | NS |
| Fractional shortening (%) | 46± 1 | 45 ± 2 | NS | 50 ± 1 | 44 ± 2 | NS | NS |
| Ejection time (ms) | 43.4 ± 0.6 | 42.7 ± 1.2 | NS | 41.9 ± 1.7 | 43.3 ± 2.3 | NS | NS |
| UA PSV (mm s−1) | 413 ± 50 | 447 ± 43 | NS | 420 ± 39 | 516 ± 51 | NS | NS |
| UA EDV (mm s−1) | 151 ± 17 | 237 ± 22 | <0.05 | 237 ± 24 | 270 ± 27 | NS | <0.05 at P14 |
| UA TAmax velocity (mm s−1) | 238 ± 27 | 296 ± 28 | NS | 272 ± 23 | 336± 33 | NS | NS |
| WT pups | BKCa +/− pups | ||||||
|---|---|---|---|---|---|---|---|
| Number of pups per litter | 8.6 + 0.2 [5] | 8.6 + 0.3 [18] | NS | 5.3 + 1 [6] | 7 + 0.4 [7] | NS | <0.05 at P14 and P18 |
| Crown–rump length (mm) | 10.7 ± 0.3 | 16.8 ± 0.5 | <0.05 | 10.3 ± 0.4 | 16.2 ± 0.6 | <0.05 | NS |
| Placental thickness (mm) | 2.6 ± 0.2 | 2.8 ± 0.2 | NS | 2.4 ± 0.2 | 3.3 ± 0.1 | <0.05 | NS |
| Fetal heart rate (beats min−1) | 186.8 ± 5.7 | 243.3 ± 7.1 | <0.05 | 207.6 ± 12.0 | 230.3 ± 6.5 | NS | NS |
| UmbA TAmax velocity (mm s−1) | 126 ± 7 | 166 ± 10 | <0.05 | 124 ± 7 | 167 ± 6 | <0.05 | NS |
Data are means ± SEM. Number of dams are in parentheses, and in brackets where values were different. EDV, end‐diastolic velocity; PSV, peak systolic velocity; TAmax, time‐averaged maximum velocity; UmbA, umbilical artery. Significance columns (P) indicate differences between pregnancy stages or genotypes. NS, not significant. Two‐way ANOVA, Sidak.