Table 1.
Haemodynamic data for the in vivo experiments
| l‐NNA group (n = 11) | Constriction group (n = 7) | |||
|---|---|---|---|---|
| Baseline | l‐NNA | Baseline | Aortic constriction | |
| Heart rate (bpm) | 110 ± 14 | 100 ± 14a | 105 ± 17 | 111 ± 17 |
| Cardiac output (L min−1) | 3.12 ± 0.68 | 2.56 ± 0.44a | 3.07 ± 0.65 | 3.67 ± 0.88 |
| Cx flow (mL min−1) | 29.5 ± 11.6 | 43.2 ± 17.7b | 32.1 ± 16.1 | 58.6 ± 19.9c |
| Cx effective vascular resistance (mmHg.min mL−1) | 2.44 ± 1.18 | 3.13 ± 1.60a | 2.37 ± 0.99 | 2.13 ± 0.80 |
| Ao systolic BP (mmHg) | 75.5 ± 7.7 | 134.5 ± 11.9c | 79.5 ± 7.6 | 147.4 ± 7.6c |
| Ao mean BP (mmHg) | 66.3 ± 9.1 | 123.9 ± 11.2c | 70.5 ± 9.2 | 121.8 ± 8.8c |
| Ao diastolic BP (mmHg) | 58.1 ± 10.0 | 115.5 ± 10.6c | 62.4 ± 10.5 | 103.0 ± 11.4c |
| Ao pulse BP (mmHg) | 17.4 ± 3.9 | 19.0 ± 2.6 | 17.0 ± 4.3 | 44.3 ± 9.9c |
| LV dP/dtmin (mmHg s−1) | −1195 ± 191 | −1878 ± 370c | −1271 ±294 | −2126 ± 443c |
| LV τ (ms) | 27.8 ± 4.7 | 19.3 ± 4.6c | 29.1 ± 5.9 | 21.5 ± 8.7a |
Ao, aortic; BP, blood pressure; Cx, circumflex coronary artery; dP/dtmin, maximal rate of pressure fall; LV, left ventricular; τ, time constant of isovolumic relaxation.
a P < 0.05, b P ≤ 0.01, c P < 0.001 compared with baseline.
Baseline variables between l‐NNA and aortic constriction groups were not significantly different.