Fig. 4.

Downregulation of miR-889 mediates the enhancement of NK cytotoxicity by sodium valproate. a Analysis of miR-889 expression in HCC cells exposed to vehicle or sodium valproate by qRT-PCR analysis. ^* P < 0.05 versus vehicle control. b qRT-PCR analysis of MICB mRNA expression in HCC cells pre-transfected with miR-889-expressing plasmid or vector 24 h before sodium valproate exposure. c HCC cells with the same treatments as in b were incubated with NK-92 cells at indicated effector to target cell ratios and subjected to NK cell-mediated cytotoxicity assay. Data are representative of three independent experiments. *P < 0.05