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. 2018 Mar 14;9(3):405. doi: 10.1038/s41419-018-0439-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The expression profiles of potential targets of miR199a-5p in male HFD-fed C57BL/6J WT mice expressing miR199a-5p. b The expression profiles of potential targets of miR199a-5p in male C57BL/6J WT mice overexpressing miR199a-5p. The two-tailed Student's t-test was applied to determine the difference between the Ad-miR199a-5p group and the corresponding control or the Ad-anti-miR199a-5p group and the corresponding control (*P < 0.05, ***P < 0.001), n = 6-8. c Sequence alignment of miR199a-5p within the 3ʹ-UTRs of human and mouse ATG14. The seed region of miR199a-5p is GUGACC. d HEK cells were co-transfected with the psiCHECK2-promoter vector and the WT 3ʹ-UTR report plasmid of ATG14 or the mutated 3ʹ-UTR report plasmids of ATG14 (Mut ATG14) with miR199a-5p (Ad-miR199a-5p) or the negative control (Ad-miR NC), and the luciferase signal was determined. The two-tailed Student's t-test was applied to determine the difference between the psiCHECK2 group and the WT 3ʹ-UTR group (**P < 0.01) or the psiCHECK2 group and the Mut 3ʹ-UTR group (NS, P > 0.05)