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. 2018 Mar 14;9(3):405. doi: 10.1038/s41419-018-0439-7

Fig. 3. miR199a-5p regulates autophagy in vivo.

Fig. 3

a ATG14, BECLIN1 and LC3 expression levels in male HFD-fed C57BL/6J WT mice expressing miR199a-5p. b ATG14, BECLIN1 and LC3 expression levels in male C57BL/6J WT mice overexpressing miR199a-5p. c Representative electron microscopic images in male HFD-fed C57BL/6J WT mice expressing miR199a-5p. Arrows indicate autophagosomes/autolysosomes. d Representative electron microscopic images in male C57BL/6J WT mice overexpressing miR199a-5p. Arrows indicate autophagosomes/autolysosomes. e, f Quantification of autophagosome/autolysosome vacuoles per field in the EM images. The two-tailed Student's t-test was applied to determine the difference between the Ad-anti-miR199a-5p group or the Ad-miR199a-5p group and the corresponding control group (**P < 0.01)