Fig. 4.

Sensitivity and specificity of ^99mTcO₄⁻ uptake in vivo. a Differing doses of 4P28ζN⁺ T cells injected subcutaneously over the shoulders were quantified by SPECT/CT. Data was corrected to thigh to account for blood pooling. n = 6 animals/group, expressed as mean ± SEM. b Linear regression of data in a. Representative SPECT/CT images for all dose levels shown in c. Animals with established (14 days) PLP xenografts were given ACT with 1 × 10⁶ 4P28ζN⁺ T cells. Seven days post-ACT, animals were given i.p. injections of either (d) PBS or (e) sodium perchlorate (10 mg/ml in PBS) 30 min before infusion of 20 MBq ^99mTcO₄. SPECT/CT images for all individual animals shown