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. 2018 Mar 14;9:1081. doi: 10.1038/s41467-018-03524-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In a ‘high tumor burden’ model, SPECT-CT imaging shows rapid 4P28ζN T-cell accumulation within the tumor mass. a Burden of subcutaneous firefly luciferase-expressing PL and PLP tumors was assessed by BLI over a period of 21 days. n = 3 animals/group. Graphs present individual animal BLI signals. b Tumor growth at day 14 and day 23 as assessed by BLI. n = 3 animals/group. Graph presents mean + s.e.m. c ^99mTcO₄⁻ activity in the tumor was quantified through 3D ROI analysis and normalized to baseline. n = 3 animals/group. Graphs present individual animal SPECT signals. d SPECT-CT images depicting the accumulation of NIS-expressing T cells in the tumors (indicated by the yellow arrows) of the individual animals (p.t = post-therapy; ^† = dead animal)