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. 2018 Mar 14;9:1088. doi: 10.1038/s41467-018-02973-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Large differences in seizure termination delays can arise between different ictal clusters involving distant and not well connected brain regions. a Pairwise correlations as a function of the pairwise termination delays for stereotactic contacts from an example seizure (Fig. 1). Green and violet dots identify clusters based on the pairwise termination delays. b Mean pairwise correlation between contacts as a function of the corresponding pairwise termination delays for all contacts, patients and seizures. Each point corresponds to the mean for each one of the clusters obtained as in a. Each color/symbol indicates a different patient. The vertical and horizontal bars indicate the standard deviation in the corresponding coordinate. Note the log scale in the x-axis. c Mean pairwise number of tracks between contacts as a function of corresponding pairwise termination delays. Same conventions as in b. Note the log scale in both the x- and y-axes. d Mean pairwise contact proximities as a function of corresponding pairwise termination delays. A value of one indicates that all pairwise contacts in the cluster are in contiguous brain regions. Same conventions as in b. e Whisker plots for pairwise correlation, number of tracks, and contact proximities for cluster one (smallest termination delays) vs. the other clusters (longer termination delays) across patients. Statistically significant differences are indicated (**P < 0.01; Mann–Whitney U-test, n = 60)