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. 2018 Mar 8;9:133. doi: 10.3389/fneur.2018.00133

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Copyright © 2018 Tanaka, Ogawa, Mukai, Sato, Hamazaki, Nagamura-Inoue, Harada-Shiba, Shintaku and Tsuji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The experimental scheme. At postnatal day 12 (P12), mice underwent permanent middle cerebral artery occlusion (MCAO). Two days after the injury (P14), they were administered vehicle or umbilical cord-derived mesenchymal stem cells (UC-MSCs) intravenously (i.v.). (Cohort A) Systemic and cerebral blood flows were measured at P14 and P15, respectively. Neurological behavioral measurements were performed at P15–P23. After sacrifice, morphological and immunohistopathological assessments were conducted in this cohort. (Cohort B) Mouse serum and cerebrospinal fluid (CSF) were collected at P15 for evaluation of a trophic factor. (Cohort C) In vivo imaging was performed at different time points after UC-MSC administration: 3 h, 24 h, 48 h, 4 days, and 7 days after injection.