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. 2018 Mar 8;9:133. doi: 10.3389/fneur.2018.00133

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Copyright © 2018 Tanaka, Ogawa, Mukai, Sato, Hamazaki, Nagamura-Inoue, Harada-Shiba, Shintaku and Tsuji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood flow measurements. (A) Representative images of systemic blood flow before and immediately after umbilical cord-derived MSC administration. (B) Systemic blood flow presented as a ratio to the pre-injection level. There were no significant differences between the vehicle and UC-MSC groups in systemic blood flow (vehicle n = 7, low-dose n = 8, and high-dose n = 8). (C) Representative images of cerebral blood flow (CBF) 24 h after administration. CBF decreased in the middle cerebral artery (MCA) region on the ipsilateral side of middle cerebral artery occlusion. (D) The CBF ratio of ipsilateral/contralateral hemispheres in the penumbra significantly decreased after MCAO. UC-MSC injection did not increase the CBF ratio. **p < 0.01 and *p < 0.05 (sham n = 10, vehicle n = 10, low-dose n = 10, and high-dose n = 12).