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. 2018 Mar 14;8:4530. doi: 10.1038/s41598-018-22749-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Escalation of systemic flow rate in 4-MPS platform enhances molecular exchange between MPSs without apparent alteration of MPS functionality. Measurements of the concentration of human serum albumin (produced by the liver MPS; red dots) and QSP model fits to the experimental data (Whisker plot indicating median, min-max values) for the mixer and for each individual MPS (liver, lung, endometrium, and gut) for baseline systemic flow rate Q_sys = 5 ml/day (left panel) and increased systemic flow rates of Q_sys = 15 ml/day (middle panel) and Q_sys = 30 ml/day (right panel). The total production rate of albumin is not affected by the flow escalation.