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Inside-out patch clamp recordings of WT and TRPM4 variants. (A) Individual current traces of WT TRPM4 and TRPM4 variants after applying 300 μM Ca2+. (B) Quantification of currents of WT and cardiac conduction disorders variants. **P < 0.005; ***P < 0.001 (WT, n = 13; A101T, n = 7; Q854R, n = 7; S1044C, n = 6; P1204L, n = 7; A101T/P1204L, n = 11).
