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. 2018 Mar 14;9(3):396. doi: 10.1038/s41419-018-0432-1

Fig. 10. Schematic diagram showing the mechanisms by which circHECTD1/HECTD1 regulate the SiO2-induced EndMT.

Fig. 10

circHECTD1 expression is increased in endothelial cells exposed to SiO2. The increased expression leads to a subsequent decrease in HECTD1 expression, which, in turn, increases the levels of mesenchymal markers and decreases the levels of endothelial markers. Endothelial cell proliferation and migration are triggered, thereby contributing to irreversible fibrosis in patients with silicosis