Fig. 1.

The regulatory landscape of the Nppa-Nppb locus. a Developmental and stress response regulatory regions of Nppa and Nppb are located within a 60 kbp domain between two CTCF sites arranged in a convergent orientation [49, 91]. Purple, shared regulatory regions of Nppa/Nppb; green, regulatory regions of Nppa; red, regulatory regions of Nppb. Gray bars, BAC clones. Displaying EMERGE track for heart and H3K27ac track for mouse cardiomyoyctes [92, 93]. b Nppa and Nppb are regulated by different regulatory elements during stress. The Nppa promoter interacts with Nppb promoter and several distal and proximal regulatory elements. Stress-induced expression of Nppb is regulated by a upstream regulatory region and the Nppa/Nppb promoters