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. 2018 Jan 15;32(3):175–181. doi: 10.1007/s12149-018-1231-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Early and late HMR in younger and older individuals. Early (a) and late (b) HMR in younger (age < 63 years) and older (≥ 63 years) individuals. Red and blue symbols, female and male individuals, respectively. Unfilled and filled symbols, younger (age < 63 years) and older (age ≥ 63 years) individuals, respectively. Box plot indicates median, 25 and 75% quartiles with whiskers at both ends. Green lines, mean values. Dotted line, HMR = 2.2 (lower limit of normal) as used in Japan using the JSNM working group database [15]