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. 2018 Mar 14;8:4529. doi: 10.1038/s41598-018-22574-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HLA versus Age at Diagnosis. (A) Patients with the highest risk HLA-DR3/DR4 had a lower age at diagnosis. Kruskal-Wallis ANOVA with Dunn’s posttest **P < 0.01, ***P < 0.001. (B) Stacked histogram depicting the cumulative number of patients grouped by HLA type versus their ages at diagnosis (4 year binned). (C) Stacked histogram depicting the cumulative percent of patients grouped by HLA type versus their ages at diagnosis (4 year binned). (B,C) HLA-type is indicated by color as shown within the figure, and 8-year and 16-year age cutoffs are indicated by dashed lines.